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. 2010 May 25;7:25. doi: 10.1186/1476-9255-7-25

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Copyright ©2010 Zins et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Severe thermal injury at a remote distal site attenuates ear-hole wound closure and tissue regeneration in MRL/MpJ mice. (A) Time course of ear-hole closure in thermally injured and solely ear-hole wounded MRL/MpJ mice. Data represent mean percent ear-hole closure ± 1 SD of ten animals in each group. (B) Macroscopic changes in ear-hole healing control and thermally injured mice. Representative photographs of the ear-hole wound sites at the indicated time post injury. The arrow points to a ear-hole wound that is 85% closed. (C) Representative histological sections of ear wound margin tissue 9 and 21 days after full-thickness third degree thermal injury (original magnification, × 40)