Table 2.
Association between health behaviors and cognitive function as a function of APOE ε4 status adjusted for socioeconomic variables.
| Memory | Reasoning | Phonemic fluency | Semantic fluency | p for interaction‡ | |
|---|---|---|---|---|---|
| Health behaviors | Difference† (95% CI) | Difference† (95% CI) | Difference† (95% CI) | Difference† (95% CI) | |
| Current smoking§ | |||||
| APOE ε4 non-carriers | -2.49 (-3.37, -1.60)* | -2.88 (-3.74, -2.01)* | -2.66 (-3.56, -1.76)* | -2.38 (-3.28, -1.47)* | |
| APOE ε4 carriers | -0.34 (-1.79, 1.11) | -1.92 (-3.31, -0.51)* | -0.35 (-1.82, 1.11) | -0.34 (-1.74, 1.06) | |
| p for interaction | 0.01 | 0.24 | 0.008 | 0.02 | 0.04 |
| Past smoking§ | |||||
| APOE ε4 non-carriers | -0.21 (-0.89, 0.44) | -0.44 (-1.08, 0.20) | 0.05 (-0.62, 0.72) | -0.39 (-1.06, 0.28) | |
| APOE ε4 carriers | 0.71 (-0.35, 1.78) | 0.08 (-0.95, 1.11) | 1.35 (0.27, 2.42)* | 1.27 (0.25, 2.30)* | |
| p for interaction | 0.11 | 0.36 | 0.04 | 0.006 | 0.02 |
| Alcohol abstinence# | |||||
| APOE ε4 non-carriers | -1.24 (-2.18, -0.30)* | -3.80 (-4.71, -2.90)* | -3.05 (-4.00, -2.10)* | -2.57 (-3.52, -1.61)* | |
| APOE ε4 carriers | -2.16 (-3.62, -0.71)* | -3.04 (-4.44, -1.63)* | -2.88 (-4.34, -1.41)* | -3.06 (-4.46, -1.66)* | |
| p for interaction | 0.22 | 0.43 | 0.88 | 0.48 | 0.37 |
| High alcohol consumption# | |||||
| APOE ε4 non-carriers | 0.63 (-0.08, 1.34) | 1.15 (0.47, 1.84)* | 1.13 (0.41, 1.85)* | 1.19 (0.47, 1.91)* | |
| APOE ε4 carriers | 1.19 (0.05, 2.32)* | 0.90 (-0.19, 1.99) | 1.96 (0.82, 3.10)* | 0.77 (-0.33, 1.86) | |
| p for interaction | 0.39 | 0.73 | 0.23 | 0.55 | 0.31 |
| Sedentary habit** | |||||
| APOE ε4 non-carriers | -0.90 (-1.55, -0.20)* | -1.20 (-1.90, -0.50)* | -1.50 (-2.23, -0.80)* | -1.50 (-2.18, -0.80)* | |
| APOE ε4 carriers | -0.60 (-1.73, 0.53) | -1.30 (-2.43, -0.30)* | -1.30 (-2.46, -0.20)* | -2.00 (-3.12, -1.00)* | |
| p for interaction | 0.92 | 0.72 | 0.90 | 0.25 | 0.70 |
| Fruit & vegetable consumption less than 2 times/day†† | |||||
| APOE ε4 non-carriers | -1.50 (-2.15, -0.90)* | -3.20 (-3.83, -2.60)* | -2.10 (-2.75, -1.50)* | -3.10 (-3.73, -2.50)* | |
| APOE ε4 carriers | -1.20 (-2.16, -0.20)* | -3.00 (-3.92, -2.00)* | -1.30 (-2.29, -0.30)* | -2.70 (-3.67, -1.80)* | |
| p for interaction | 0.45 | 0.59 | 0.15 | 0.46 | 0.69 |
* p < 0.05.
† Mean difference in T-score of cognitive function in models adjusted for age and sex. ‡ p from MANCOVA.
§Difference with never smoking. # Difference with moderate alcohol consumption.
** Difference with non sedentary habit. †† Difference with the group eating fruit & vegetables 2 or more times a day.