BOLD deactivation (as percent signal change) in mPFC (data extracted from a 5 mm sphere centered on x = 0, y = 54, z = 3). Plot displays mean (dark grey circles HC, light grey FH); error bars show SE. BOLD, blood oxygenation level-dependent; FH, people who had a depressed parent but no personal history of depressive illness; HC, healthy control subjects with no family history of depression; mPFC, medial prefrontal cortex; SE, standard error of the mean.