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. 2010 Feb 23;18(5):873–880. doi: 10.1038/mt.2010.17

Figure 6.

Figure 6

Rocking rotarod performance as a function of age in each treatment group. Mean duration of the time spent on a rocking (reversing) rotarod as a function of increasing age for all treated and normal control groups is depicted. No performance deficits were evident in the untreated MPS IIIB mice (or in the other treated groups) compared to normal controls during the predysfunction period (168, 196, 224, and 252 days). However, a significant main effect of group (*P = 0.048) and a significant group by age interaction (**P = 0.008) suggest that age-dependent group performance differences occurred during the progressive impairment period (280, 308, 336, and 364 days). Pairwise comparisons showed that on average across the ages at testing, the MPS IIIB mice were significantly impaired relative to normal control mice (P = 0.004) and that MPS IIB-AAV mice showed improved performance compared to MPS IIB mice (P = 0.040). Subsequent one-way analysis of variances conducted at each age showed that these effects were mostly due to differences observed at 364 days (P = 0.005). At this age, the untreated MPS IIIB mice showed performance deficits compared to the normal controls (†P = 0.0006), and MPS IIIB-AAV mice exhibited significantly improved performance levels relative to the untreated MPS IIIB mice (††P = 0.010). AAV, adeno-associated virus; BMT, bone marrow transplant.