Table 2.

Determination of vector genome copy number after ATVRX delivery of an AAV2-cFIX vector

Biopsy site	DLAM 3, vg/diploid genome	DLAM 4, vg/diploid genome
Target limb
1	0.163 ± 0.111	0.09*
2	0.091 ± 0.012	0.186 ± 0.251
3	14.018 ± 1.479	9.146 ± 1.587
4	6.058 ± 0.591	0.505 ± 0.057
5	0.019 ± 0.005	5.358 ± 0.592
Contralateral limb
1	0.004 ± 0.001
2	0.014 ± 0.015	0.094 ± 0.108
3	0.004 ± 0.003
4	0.004 ± 0.001
5	0.004 ± 0.004	0.012 ± 0.003

Results are expressed as average ± SD. All the experiments were repeated twice using 500 to 1000 ng of genomic DNA per reaction.

^*Single experiment with 344 ng of genomic DNA in the reaction.