Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Isotype switched IgG BCRs efficiently initiate early events in BCR signaling. Shown are IgM BCRs (top) and IgG BCRs (bottom). The IgM and IgG BCRs bind antigen similarly in an affinity dependent fashion that brings the BCRs into an oligomerization-permissive conformation. However, because of the properties of its cytoplasmic tail the IgG BCRs oligomerize and initiate signaling more efficiently.
