Table III.
MTHFR 677C>T and 1298A>C Polymorphisms and risk1 for spontaneous abortions in a Mexican perinatal cohort. Morelos, México, 2001–2004
| Polymorphisms | All | Early Abortions (≤ 10 weeks) | Late Abortions (> 10weeks) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR1 | 95%CI | Cases | Controls | OR2 | 95%CI | Cases | Controls | OR3 | 95%CI | |
| MTHFR 677C>T* | ||||||||||
| CC+CT | 1.0 | -- | 5 | 55 | 1.0 | -- | 8 | 55 | 1.0 | -- |
| TT | 5.0 | 1.2, 20.9 | 4 | 19 | 5.2 | 0.75,35.6 | 6 | 19 | 5.8 | 0.82,41.1 |
| MTHFR 1298A>Cठ| ||||||||||
| AA | 1.0 | -- | 8 | 60 | – | – | 9 | 60 | 1.0 | – |
| AC | 5.5 | 1.1, 26.6 | 1 | 14 | – | – | 4 | 14 | 9.7 | 1.4,68.8 |
*
Risk adjusted for maternal occupation, MTHFR 1298A>C, folate intake and caloric intake and husbands’ smoking status.
‡
Risk adjusted for maternal occupation MTHFR 677C>T, folate intake and caloric intake and husband’s smoking status
§
1 case had missing values for the MTHFR 1298A>C