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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Behav Pharmacol. 2010 Mar;21(2):135–143. doi: 10.1097/FBP.0b013e328337be7e

Figure 3. Effects of 0.3-3.0 mg/kg PRA on PPI and startle magnitude (inset) across varying prepulse time intervals in C57BL/6J mice (Exp. 3).

Figure 3

Due to the absence of evidence of bioactivity in Exps. 1 and 2, PRA doses were shifted higher to 0.3, 1.0, and 3.0 mg/kg for Exp. 3. Prepulses were 8 dB(A) above background, and preceded the pulse by 10, 20, 30, 60, or 120 ms (onset-to-onset). Even at the highest dose, there was no significant effect on startle magnitude. Data are mean ± SEM. (n = 4-5 mice per dose group)