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. Author manuscript; available in PMC: 2011 May 28.
Published in final edited form as: J Nat Prod. 2010 May 28;73(5):956–961. doi: 10.1021/np100228d

Figure 3. Compounds 1, 2, and pawpaw crude extract inhibit the induction of HIF-1α protein in the nucleus.

Figure 3

(A) Western blot analysis of HIF-1α and HIF-1β proteins in nuclear extract samples from T47D cells exposed to hypoxia in the presence and absence of 1, 2, and CE. (B) Subcellular localization of HIF-1α protein in T47D cells exposed to hypoxia in the presence and absence of 1 (0.3 μM), 2 (0.3 μM), and CE (0.3 μg/mL). The left column shows an immunofluorescence stain for HIF-1α protein, the middle column DAPI stain for nuclei, and the right column merged images.