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. 2010 Jul;33(7):1529–1535. doi: 10.2337/dc09-0354

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© 2010 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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Effects of hyperinsulinemic euglycemia and hypoglycemia (2.9 ± 0.1 mmol/l) in overnight-fasted healthy control subjects (n = 35) and subjects with type 1 diabetes (n = 24) that participated in either one or both of the studies on vascular biological markers. Responses of PAI-1, P-selectin, IL-6, and adiponectin are significantly increased during hypoglycemia as compared with euglycemia in healthy control subjects. Responses of P-selectin, IL-6, and adiponectin are significantly increased during hypoglycemia as compared with euglycemia in type 1 diabetes. Statistical difference with two-way ANOVA during the 120-min clamp experiments is marked in each graph panel.