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. 2010 Jun;60(3):205–217.

Figure 3.

Figure 3.

Ineffective myelinating activity by oligodendrocytes of the spinal cord and optic nerve of (A through C) adult LES and (D through F) LE-bo rats. (A) LES rat, 16 wk of age. An oligodendrocyte extends its perikaryon in attempt to myelinate a large adjacent axon (asterisk) with an incomplete myelin sheath. Bar, 2 μm. (B) Detail of the incomplete myelin sheath in panel A. Bar, 500 nm. (C) LES rat, 69 wk. A cluster of glial cells interpreted as immature oligodendrocytes is surrounded by naked axons separated from each other by severe astrogliosis, with the exception of one axon that is surrounded by a single lamella (asterisk). Bar, 2 μm. (D) LE-bo rat, 45 wk. Several axons have thin uncompacted and sometimes incomplete sheaths. Bar, 1 μm. (E) LE-bo rat, 45 wk. An oligodendrocyte forms a few incompacted myelin lamellae against adjacent axons (asterisks), and its perikaryon is distended by honeycombs. Bar, 1 μm. (F) Detail of the wall of a honeycomb encompassing stacks of multiple membranes (arrowheads) and of incompacted myelin adjacent to the oligodendrocyte (arrows). Bar, 200 nm.