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. 2010 Jun;60(3):205–217.

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Figure 5. — Glial cell plasticity in old LES and LE-bo rats. (A) LES rat, 24 wk of age. A mature oligodendrocyte forms incompacted myelin lamellae against its membrane (open arrowheads) and contains numerous honeycombs scattered in the perikaryon (short arrows). Adjacent is a cluster of 4 immature glial cells. Bar, 2 μm. (B) LES rat, 69 wk. Several immature glial cells are scattered among naked axons, which are separated from each other by astrogliosis. Bar, 4 μm. (C) LE-bo rat, 45 wk. A cluster of immature glial cells of oligodendrocyte-type are adjacent to an astrocyte (As). In the surrounding area are scattered axons with thin myelin sheaths (asterisks). The arrow indicates an oligodendrocyte-type cell with multiple vesicles in the perikaryon, which are considered to be degenerative changes. Bar, 4 μm. (D) Area indicated by the arrow in panel C. An oligodendrocyte-type cell with formation of vesicles in the perikaryon, which are considered to be degenerative changes. Bar, 500 nm.