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. 2010 May 17;107(22):10208–10213. doi: 10.1073/pnas.0907011107

Fig. 4.

Fig. 4.

Box plots showing relative expression of the PIK3CA mt (A) and PTEN-loss (B) gene signatures according to molecular subtype and PI3K pathway aberration from the Saal et al. (19) dataset. PIK3CA-sequenced mutants (HD+KD) have less expression of the PTEN-loss gene signature compared with BCs that are PTEN-deficient by IHC (P = 0.001) or HER2-amplified (P = 0.01), but still higher expression compared with the ER+/HER2−/L (Luminal-A) tumors (P = 0.002).