Table 3.

Multivariate analysis in patients with ER+ BC who had received adjuvant tamoxifen (TAM dataset, n = 302)

Factor	HR (95% CI)	P Value
Age (binary)	1.9 (0.4–8.1)	0.4
Nodal status	1.6 (0.8–3.1)	0.2
Tumor size (binary)	1.9 (1.1–3.3)	0.03
Histologic grade	2.4 (0.9–6.2)	0.07
PIK3CA-GS	0.5 (0.3–0.8)	0.01

Patients were included from the TAM dataset who had all data available for analysis. All BC subtypes are defined using gene expression; HR, hazard ratio. In multivariate analysis, factors were treated as follows: age ≤50 y vs. >50 y; nodal status: positive vs. negative; tumor size: ≤2 cm vs. >2 cm; histologic grade 3 vs. 1 and 2. Endpoint is distant metastases.

*PIK3CA-GS treated as a continuous variable (cut-off independent).