Table 2.
Top-20 high-traffic proteins in the HF core network.
| Protein | Network module | BP | CC | Traffic |
|---|---|---|---|---|
| FN1 | 7 | cell adhesion, response to wounding | extracellular region | 140037.9 |
| PDGFRB | 16 | positive regulation of cell proliferation, positive regulation of cell migration | ? | 118789.9 |
| ITGB1 | 13 | homophilic cell adhesion, leukocyte adhesion | cell surface | 107208.2 |
| C3 | 1 | G-protein coupled receptor protein signaling pathway | extracellular region | 53979.1 |
| COL1A1 | 7 | blood vessel development | plasma membrane | 48837.3 |
| TGFB1 | 6 | connective tissue replacement during inflammatory response | extracellular region | 45861.8 |
| MMP2 | 9 | proteolysis | extracellular space | 43355.8 |
| PTEN | 17 | regulation of cyclin-dependent protein kinase activity | cytoplasm | 43018.0 |
| CHGB | 17 | ? | ? | 42398.0 |
| ITGB3 | 7 | blood coagulation | integrin complex | 41256.5 |
| ADAM15 | 16 | cell-matrix adhesion | ? | 36080.8 |
| IL6ST | 16 | positive regulation of cardiac muscle hypertrophy | interleukin-6 receptor complex | 35295.1 |
| COL2A1 | 7 | collagen fibril organization | collagen type II | 33618.7 |
| TNFSF11 | 9 | immune response | extracellular region | 32703.6 |
| ITGAV | 9 | cell adhesion | cytoplasm | 31291.3 |
| PDGFRA | 16 | cell activation | integral to plasma membrane | 31130.0 |
| LRP1 | 9 | lipid metabolic process | membrane fraction | 30483.8 |
| SRC | 16 | protein kinase cascade | plasma membrane | 28672.6 |
| MMP9 | 9 | macrophage differentiation | extracellular space | 27463.8 |
| TNF | 12 | anti-apoptosis | plasma membrane | 27462.7 |
Bold rows highlight proteins known to be HF biomarkers. For each protein, BP and CC represent examples of biological processes and cellular localization annotations respectively assigned to the protein, as defined in the GO. "?" means that no GO annotation was found for the protein (as of January 2009).