Table 1.
Correlation between methylation of DDIT3 gene and the clinical characteristics of CML patients.
| Status of DDIT3 methylation | ||||
|---|---|---|---|---|
| Patient's parameters | Patients with methylated DDIT3 (n = 35) |
Patients with unmethelated DDIT3 (n = 18) |
Total (n = 53) |
P value |
| Ages (yr) 1 | 48 (21-73) | 40 (17-83) | 45 (17-83) | 0.225 |
| Sex (male/female) | 28/7 | 10/8 | 38/15 | 0.106 |
| WBC (×109/L) 1 | 38.0 (2.2-178.6) | 161.8 (4.1-235.2) | 75.6 (2.2-235.2) | 0.007 |
| Hemoglobin (g/dL)1 | 9.9 (4.9-14.8) | 9.3 (5.2-14.3) | 9.5 (4.9-14.8) | 0.963 |
| Plateletcounts (×109/L) 1 | 264 (20-1494) | 263 (24-870) | 264 (20-1494) | 0.844 |
| Cytogenetics | 0.542 | |||
| t(9;22) | 26 (63%) | 15 (37%) | 41 | |
| variant t(9;22) | 2 (100%) | 0 (0%) | 2 | |
| t(9;22) with additional alteration | 7 (70%) | 3 (30%) | 10 | |
| Staging | 0.256 | |||
| CP | 24 (68%) | 11 (32%) | 35 | |
| AP | 3 (100%) | 0 (0%) | 3 | |
| BC | 8 (53%) | 7 (47%) | 15 | |
| bcr/abl transcript | 4.82 (0.28-877.94) | 3.37 (0.26-221.77) | 3.96 (0.26-877.94) | 0.583 |
| DDIT3 transcript | 2.13 (0.05-65.32) | 3.92 (0.12-126.04) | 3.28 (0.05-126.04) | 0.152 |
WBC, white blood cells; CP, chronic phase; AP, accelerated phase; BC, blast crisis. 1 Median (range).