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. 2010 Jun 3;29(1):63. doi: 10.1186/1756-9966-29-63

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Copyright ©2010 Chuan et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The morphologic changes of each group cells observed by electromicroscope. Antisense group showed more cell degeneration and necrosis, with cell volume enlargement, chromatin margination and dissolving and lipid droplets within the cytoplasm increase, endoplasmic reticulum dilation, and swelling of mitochondria like vacuoles. Occasional plasma membrane rupture and cell collapse were also seen. (a: control group(original magnification × 10000 b: antisense group(original magnification × 4000).