Table 1. GO term analysis of differentially expressed genes between the C and B6a strains at 4 and 8 months-of-age.
|
GOID |
GO Name |
Number changed |
Percent changed |
Z score |
Permute P statistic |
| GO terms increased in C versus B6a at 4 months | |||||
|---|---|---|---|---|---|
| 16628 |
oxidoreductase activity\, acting on the CH-CH group of donors\, NAD or NADP as acceptor |
5 |
55.6 |
4.8 |
<0.001 |
| 30054 |
cell junction |
25 |
21.9 |
4.746 |
<0.001 |
| 8305 |
integrin complex |
7 |
41.2 |
4.6 |
<0.001 |
| 4716 |
receptor signaling protein tyrosine kinase activity |
5 |
57.1 |
4.4 |
<0.001 |
| 44420 |
extracellular matrix part |
15 |
21.7 |
3.6 |
<0.001 |
| 16769 |
transferase activity\, transferring nitrogenous groups |
8 |
33.3 |
4.1 |
0.001 |
| 45111 |
intermediate filament cytoskeleton |
11 |
26.8 |
3.9 |
0.001 |
| 6958 |
complement activation\, classical pathway |
5 |
38.5 |
3.7 |
0.001 |
| 42060 |
wound healing |
13 |
22.8 |
3.6 |
0.003 |
|
GO terms increased in B6a versus C at 4 months | |||||
| 42401 |
biogenic amine biosynthetic process |
6 |
35.3 |
4.4 |
<0.001 |
| 299 |
integral to membrane of membrane fraction |
4 |
44.4 |
4.3 |
0.001 |
| 42398 |
amino acid derivative biosynthetic process |
6 |
27.3 |
3.6 |
0.003 |
| 7222 |
Wnt receptor signaling pathway |
4 |
40.0 |
4.0 |
0.004 |
| 46916 |
transition metal ion homeostasis |
7 |
23.3 |
3.4 |
0.006 |
| 19886 |
antigen processing and presentation of exogenous peptide antigen via MHC class II |
4 |
30.8 |
3.2 |
0.006 |
| 1664 |
G-protein-coupled receptor binding |
8 |
20.51282 |
3.147 |
0.007 |
| 8009 |
chemokine activity |
6 |
25.0 |
3.3 |
0.009 |
|
GO terms increased in C versus B6a at 8 months | |||||
| 3924 |
GTPase activity |
26 |
19.0 |
3.3 |
<0.001 |
| 6898 |
receptor-mediated endocytosis |
8 |
32.0 |
3.6 |
0.001 |
| 5606 |
laminin-1 complex |
4 |
57.1 |
4.1 |
0.002 |
| 5740 |
mitochondrial envelope |
40 |
16.4 |
3.1 |
0.002 |
| 19752 |
carboxylic acid metabolic process |
54 |
15.2 |
3.1 |
0.002 |
| 30865 |
cortical cytoskeleton organization and biogenesis |
5 |
41.7 |
3.6 |
0.007 |
| 6778 |
porphyrin metabolic process |
6 |
35.3 |
3.4 |
0.009 |
| 87 |
M phase of mitotic cell cycle |
23 |
16.5 |
3.4 |
0.009 |
|
GO terms increased in B6a versus C at 8 months | |||||
| 50880 |
regulation of blood vessel size |
8 |
36.4 |
5.2 |
0 |
| 5720 |
nuclear heterochromatin |
6 |
30.0 |
3.9 |
0.001 |
| 10038 |
response to metal ion |
4 |
44.4 |
4.3 |
0.004 |
| 8083 |
Growth factor activity |
12 |
14.0 |
3.1 |
0.004 |
| 19216 |
regulation of lipid metabolic process |
5 |
26.3 |
3.2 |
0.007 |
| 1664 |
G-protein-coupled receptor binding |
8 |
20.5 |
3.1 |
0.007 |
| 42773 | ATP synthesis coupled electron transport | 5 | 26.3 | 3.2 | 0.009 |
Gene ontology (GO) terms that are over-represented among differentially expressed genes meeting the criteria Fold of change>1.2 and FDR<0.05 for each comparison were determined using MAPPFinder 2. The list of GO terms reported below was generated using the following criteria: Permute p<0.01, Z score≥2, percentage of genes changed>10% and the number of genes changed at least 4 but lower than 100. Permute P is a non-parametric statistic based on 2000 permutations of the data.