Figure 6.

Cytokine and growth factor enrichment in mammary fat pad. Interaction of cytokines and growth factors highly expressed in mammary fat pad (MFP) relative to parenchyma (PAR) with differentially expressed genes (DEG) highly expressed in PAR vs. MFP. Objects for cytokines and growth factors largely expressed in MFP vs. PAR have an orange shade. DEG largely expressed in PAR vs. MFP are depicted in blue shades. The intensity of the shaded color in the object relates to the fold-difference in MFP vs. PAR (orange) or PAR vs. MFP (blue). Molecule types have their background highlighted as follows: enzymes, yellow; cytokines and growth factors potentially secreted by MFP, red; cytokines and growth factors highly expressed in PAR vs. MFP light-green; membrane and G-coupled receptors, black (white font); phosphatase and kinases, gray; transcription factors and nuclear-dependent transcription regulators, dark-pink. All other molecules have white background. Red arrows denote effects on gene expression, purple arrows denote activation, dark-violet arrows denote phosphorylation, and green arrows denote protein-protein interaction. Arrow edges are expression (E), activation (A), modification (m), protein-protein interaction (PP), protein-RNA interaction (PR), phosphorylation (P), and translocation (TR). Legend for the shape of the objects is reported in the figure.