Table 3. Least square means (95% lower and upper confidence intervals) for body composition, metabolic, and sleep traits of study subjects stratified according to SDC4 polymorphisms.
| P* | ||||
| rs4599 | C/C | T/C | T/T | |
| n | 16 | 96 | 140 | |
| BMI | 18.94 (17.66–20.30) | 18.57 (18.03–19.13) | 18.16 (17.72–18.61) | 0.126a, 0.156d, 0.347r |
| Weight (kg) | 37.24 (34.8–39.84) | 36.26 (35.25–37.3) | 35.59 (34.47–36.43) | 0.164, 0.228, 0.305 |
| TFM (kg) | 7.74 (6.09–9.83) | 7.63 (6.92–8.42) | 7.32 (6.75–7.94) | 0.534, 0.526, 0.788 |
| LTM (kg) | 26.22 (25.14–27.34) | 25.74 (25.3–26.18) | 25.38 (25.02–25.75) | 0.087, 0.131, 0.232 |
| IAAT (cm2) | 30.78 (24.97–37.94) | 27.85 (25.49–30.42) | 28.85 (26.74–31.14) | 0.919, 0.778, 0.441 |
| SI [×10−4 min−1/(µU/mL)] | 4.65 (3.65–5.91) | 5.28 (4.80–5.80) | 4.70 (4.35–5.09) | 0.274, 0.112, 0.619 |
| Fasting Glucose (mg/dL) | 93.21 (90.02–96.40) | 97.53 (96.27–98.79) | 97.57 (96.53–98.60) | 0.104, 0.463, 0.01 |
| REE (kcal/day) | 1240 (1132–1358) | 1217 (1176–1261) | 1135 (1103–1167) | 0.002, 0.001, 0.242 |
| Hours of sleep/night | 8.35 (7.85–8.87) | 8.83 (8.61–9.06) | 8.95 (8.77–9.13) | 0.056, 0.187, 0.044 |
BMI: body mass index; TFM: total fat mass; LTM: lean tissue mass; IAAT: Intra-abdominal adipose tissue; SI: Insulin sensitivity index; REE: resting energy metabolism. Sex, age, Tanner stage, and African and European genetic admixture were used as covariates in all the analyses. Weight, TFM, and LTM were also adjusted for height. IATT, SI, fasting glucose, and REE were also adjusted for TFM. *P values represent the significance of the comparison among genotypes.
a
, d, and
r
indicate P values calculated assuming additive, dominant, and recessive models, respectively. P values <0.05 are highlighted in bold case.