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Model of HOXB13-mediated regulation of E2F signaling: Overexpression of HOXB13 in androgen-refractory prostate tumors inhibits the expression of the p21 waf tumor suppressor and subsequently activates cyclin dependent kinase 2 (CDK2) activities. Hyperphosphorylated RB releases E2F transcription factor, which drives the genes involved in cell proliferation, and results in increased cell survivability in the absence of hormone.
