Rats |
1-h or 10-min immobilization |
Estradiol vs no hormone treatment |
Positive |
[71,72] |
|
Rapid blood volume depletion |
Estradiol+progesterone+thyroxine vs no hormone treatment |
Positive |
[66] |
|
Transfer to a novel environment followed by a return to the original quarters 30 min later, or 15-min exposure to strobe light |
No hormone treatment vs estradiol |
Positive |
[72] |
Rhesus monkeys |
30-min intracerebroventricular infusion of interleukin-1α |
Estradiol at doses that result in plasma estradiol levels that reproduce the late follicular phase |
Positive |
[56] |
|
|
Estradiol at doses that result in plasma estradiol levels that reproduce the early-mid follicular phase |
No effect |
[57] |
Women |
Single intravenous injection of endotoxin |
Estradiol vs no hormone treatment |
Positive |
[35] |