Table 2.
Scatchard analysis of [3H] dopamine binding against dopamine in the cerebral cortex of control, and experimental rats
| Animal status | Bmax (fmoles/mg protein) | Kd (nM) |
|---|---|---|
| Control | 23 ± 3.7 | 2.01 ± 0.05 |
| Diabetic | 67 ± 5.7*** | 6.17 ± 0.06** |
| D + I | 19.8 ± 4.1ψψψ | 2.4 ± 0.05ψψ |
| D + C | 21.7 ± 6.6ψψψ | 1.96 ± 0.06ψψ |
Values are mean ± S.E.M of 4-6 separate experiments. Each group consist of 6-8 rats *** P < 0.001 when compared to control, ψψψP < 0.001 when compared to diabetic group **P < 0.01 when compared to control group ψψ P < 0.01 when compared to diabetic group.
D + I- Insulin treated diabetic rats
D+C- Curcumin treated diabetic rats