Table 3.
Scatchard analysis of [3H] dopamine binding against dopamine in the cerebellum of control, and experimental rats
| Animal status | Bmax (fmoles/mg protein) | Kd (nM) |
|---|---|---|
| Control | 112 ± 5.4 | 3.8 ± 0.14 |
| Diabetic | 22 ± 3.6*** | 2.3 ± 0.05** |
| D + I | 116 ± 4.3ψψψ | 3.2 ± 0.13@@ |
| D + C | 91.1 ± 3.87ψψψ | 4.0 ± 0.03@@ |
Values are mean ± S.E.M of 4-6 separate experiments. Each group consist of 6-8 rats ***P < 0.001 when compared to control, ψψψP < 0.001 when compared to diabetic group **P < 0.01 when compared to control group @@P < 0.01 when compared to diabetic group.
D + I- Insulin treated diabetic rats
D+C- Curcumin treated diabetic rats