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. 2010 Jun 7;17(1):46. doi: 10.1186/1423-0127-17-46

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Copyright ©2010 Chiang et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Tolerance development to morphine in prenatally morphine-exposed male rats. (A) The latency and AUC of rats after receiving first injection of morphine. (B) The latency and AUC of rats after receiving 7th injection of morphine. (C) Rate of tolerance development to morphine in morphine or saline prenatally exposed rats. The animals more quickly developed a tolerance to morphine than the prenatally saline-exposed controls (F_{(1, 114)}= 4.333, p < 0.05). All data are expressed as mean ± S.E.M, (N = 19 per group), *p < 0.05, ***p < 0.001 compared to saline control.