Table 1.

Effects of prenatal exposure to opioids on offspring

	Saline	Morphine	Methadone	Buprenorphine
		Mean ± SEM
Number of offspring per litter	10.9 ± 0.2	10.5 ± 0.3	9.8 ± 0.3	10.2 ± 0.3
Fatality (%)	0.69 ± 0.33	0	0	7.1 ± 2.38**
Fatality occurred in the offspring (%) (P2-P10)	0.21 ± 0.14	0	0.56 ± 0.56	12.14 ± 7.02*
Body weight increase in the dams (g) (E3-E20)	148.1 ± 2.7	132.3 ± 4.2**	121.3 ± 3.3***	136.4 ± 3.7*
Body weight of the offspring at birth (g)	6.8 ± 0.1	7 ± 0.1	6.6 ± 0.1	6.9 ± 0.1
Body weight of the offspring on day 7 (g)	14.7 ± 0.3	16.3 ± 0.5*	14.5 ± 0.4	13.5 ± 0.4*

*Significantly different compared to saline group, p < 0.05

**Significantly different compared to saline group, p < 0.01

***Significantly different compared to saline group, p < 0.001