Table 1.
Saline | Morphine | Methadone | Buprenorphine | |
---|---|---|---|---|
Mean ± SEM | ||||
Number of offspring per litter | 10.9 ± 0.2 | 10.5 ± 0.3 | 9.8 ± 0.3 | 10.2 ± 0.3 |
Fatality (%) | 0.69 ± 0.33 | 0 | 0 | 7.1 ± 2.38** |
Fatality occurred in the offspring (%) (P2-P10) | 0.21 ± 0.14 | 0 | 0.56 ± 0.56 | 12.14 ± 7.02* |
Body weight increase in the dams (g) (E3-E20) | 148.1 ± 2.7 | 132.3 ± 4.2** | 121.3 ± 3.3*** | 136.4 ± 3.7* |
Body weight of the offspring at birth (g) | 6.8 ± 0.1 | 7 ± 0.1 | 6.6 ± 0.1 | 6.9 ± 0.1 |
Body weight of the offspring on day 7 (g) | 14.7 ± 0.3 | 16.3 ± 0.5* | 14.5 ± 0.4 | 13.5 ± 0.4* |
*Significantly different compared to saline group, p < 0.05
**Significantly different compared to saline group, p < 0.01
***Significantly different compared to saline group, p < 0.001