Fig. 4.

CXCR4 activation differentially affects OPC proliferation within the SVZ and CC. (A) Confocal IHC analysis of rostral subventricular zones (SVZ) and CC from mice after 6 wk of CPZ ingestion plus 2 wk of treatment with PBS (Left) or AMD3100 (Right) with daily i.p. injection of BrDU. Images were stained for BrDU (green), NG2 (red), and nuclei (blue). Representative images shown from three sections from three individual mice per group. (Scale bars, 25 μm.) (B) Quantitation of BrDU+NG2+ cells within rostral, central, and caudal sections of the CC and SVZ of mice after 6 wk of CPZ ingestion and 2 wk of treatment with PBS (gray bars) or AMD3100 (black bars); n = 6 images taken from three mice/group, *, P < 0.05.