Oxidative stress and caspase-8 OB of KO mice. (A) Western blot analysis of protein carbonylation (Oxyblot), active caspase-9, active caspase-8, GFAP, and Iba-1 levels in OB of CT and KO mice. (B) Densitometric analysis of Western blot images in A. Integrated density values for each lane were normalized to β-actin and expressed relative to the lowest value in CT. ** P < 0.01, *** P < 0.001 vs. CT.