Fig. 2.

Validation of the model structure via mutagenesis data. Mutagenesis data mapped on the hCTR1 model. Three different views are presented. Cα-atoms of residues for which mutational data are available are shown as spheres and colored according to the functional effect of the mutation, with red and green depicting positions sensitive and nonsensitive to substitutions, respectively. Positions in which mutations induced partial function are colored yellow.