Fig. 3.

Intermolecular contacts within the Qβ replicase. Hydrogen bonds and electrostatic interactions are shown as dashed lines. (A) Details of the β-subunit (βS): β-subunit interface. (B) Contacts between the EF-Ts (Dark Red) coiled-coil motif and the β-subunit (Green) thumb domain. (C) The interface between the β-subunit and EF-Tu (Yellow) involving the T helix and bridge helix from the β-subunit and domains 1 and 3 from EF-Tu. (D). The complex of EF-Tu and aa-tRNA in the same orientation as in C. (E) Close-up of the β-subunit T-helix interaction with EF-Tu domain 2. (F) Insertion of the β-subunit thumb domain between EF-Tu domain 3 and EF-Ts.