Fig. 1.

Selective reduction in immune cell subsets induced by in vivo ABT-737 treatment is proportional to drug dosage. B6 mice were treated daily with ABT-737 (10, 19, 38, or 75 mg/kg) or vehicle (0 mg/kg) for 14 consecutive d (n = 6). After treatment, LN, spleen, and BM were recovered and the proportion of T cells (CD4⁺,CD8⁺), B cells, and DC remaining in the organs was determined by flow cytometry. All data are shown as a proportion (%) of the average number of cell subsets isolated from vehicle-treated mice, with means ± SE from individual drug-treated mice.