Comparison of connectivity maps for depressed and control subjects across three networks. Connectivity of the CCN for control participants (A), depressed participants (B), and between-group differences (C); connectivity of DMN for controls (D), depressed participants (E), and between-group differences (F); and connectivity of the AN for controls (G), depressed participants (H), and between-group differences (I). Networks were identified by seed regions placed in the DLPFC (A–C), precuneus (D–F), and subgenual ACC (G–I). In each network, the dorsal nexus is seen at z = 30. The color bar indicates that images were thresholded at z = 2.58, P < 0.01.