Table 2.
Tracheal and cloacal titers of Ck/Qal-Egypt/1/08 (H5N1) virus in chickens immunized with commercial H5 vaccines
| Vaccine | Virus titers* | |||||||
| Trachea | Cloaca | |||||||
| 3 dpc | 5 dpc | 7 dpc | 9 dpc | 3 dpc | 5 dpc | 7 dpc | 9 dpc | |
| Placebo | 3.5 ± 1.1 (3/3) | ndb | nd | nd | 1.1 ± 0.9 (3/3) | nd | nd | nd |
| Volvac H5N2 | 2.4 ± 1.6 (2/8) | 4.3 ± 0.0 (1/8) | 4.5 ± 0.0 (1/8) | 2.5 ± 0.0 (1/8) | <(0/8) | <(0/8) | <(0/8) | 3.3 ± 0.0 (1/8) |
| YEBIO H5N2 | <(0/8)† | <(0/8) | <(0/8) | <(0/8) | <(0/8) | <(0/8) | <(0/8) | <(0/8) |
| YEBIO H5N1 Re-1 | <(0/8) | <(0/8) | <(0/8) | <(0/8) | <(0/8) | <(0/8) | <(0/8) | <(0/8) |
| First H5N1 Re-5 | <(0/8) | <(0/8) | <(0/8) | <(0/8) | <(0/8) | <(0/8) | <(0/8) | <(0/8) |
| Ck/C58 H5N3‡ | <(0/8) | <(0/8) | <(0/8) | <(0/8) | <(0/8) | <(0/8) | <(0/8) | <(0/8) |
dpc, days postchallenge; nd, not determined because of death.
*Log10 EID50/mL, determined in eggs. Data are the mean ± SD from positive samples (≥0.75 log10 EID50/mL). Values in parentheses are number shedding/number tested.
†<, the titer was below the limit of detection (<0.75 log10 EID50/mL).
‡Vaccine containing 1.2 μg of HA protein of A/Chicken/Vietnam/C58/04 (H5N1).