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. 2010 May 24;107(23):10719–10724. doi: 10.1073/pnas.1005866107

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Fig. 5. — Effect of HO-2 inhibition on carotid body H₂S generation and sensory activity in CSE^+/+ and CSE^−/− mice. (A) Effect of Cr(III)MP (1 μM), an inhibitor of heme oxygenase 2 on H₂S generation in carotid bodies under normoxia ( ∼ 146 mmHg) from CSE^+/+ and CSE^−/− mice. Data presented are mean ± SEM from three experiments. Examples of baseline and hypoxic response (Hx) ( ∼ 40 mmHg; at black bar) of carotid bodies from vehicle- and Cr(III)MP-treated CSE^+/+ and CSE^−/− mice (B) and average data (mean ± SEM) from six mice in each group (n = 8–12 fibers) in C and D. In B, Integrated carotid body sensory activity (CB activity) is presented as impulses per second (imp/s). Superimposed action potentials from the single fiber are presented in Inset. *** and *, P < 0.001 and P < 0.05, respectively; n.s. (not significant), P > 0.05.

Inline graphic — Effect of HO-2 inhibition on carotid body H₂S generation and sensory activity in CSE^+/+ and CSE^−/− mice. (A) Effect of Cr(III)MP (1 μM), an inhibitor of heme oxygenase 2 on H₂S generation in carotid bodies under normoxia ( ∼ 146 mmHg) from CSE^+/+ and CSE^−/− mice. Data presented are mean ± SEM from three experiments. Examples of baseline and hypoxic response (Hx) ( ∼ 40 mmHg; at black bar) of carotid bodies from vehicle- and Cr(III)MP-treated CSE^+/+ and CSE^−/− mice (B) and average data (mean ± SEM) from six mice in each group (n = 8–12 fibers) in C and D. In B, Integrated carotid body sensory activity (CB activity) is presented as impulses per second (imp/s). Superimposed action potentials from the single fiber are presented in Inset. *** and *, P < 0.001 and P < 0.05, respectively; n.s. (not significant), P > 0.05.