Table 2.
Baseline values of Autism Diagnostic Interview Revised (ADI-R) and Autism Diagnostic Observation Schedule-Generic (ADOS-G) for treatment groups by centre
|
London |
Manchester |
Newcastle |
Total |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PACT (n=26) | TAU (n=26) | PACT (n=26) | TAU (n=26) | PACT (n=25) | TAU (n=23) | PACT (n=77) | TAU (n=75) | |||
| ADI-R* | ||||||||||
| Reciprocal social interaction | 17·6 (9–24) | 18·7 (8–26) | 18·9 (9–25) | 18·3 (8–26) | 17·0 (9–24) | 17·4 (9–24) | 17·9 (9–25) | 18·2 (8–26) | ||
| Restricted, repetitive, and stereotyped patterns | 6·2 (3–10) | 5·7 (0–10) | 5·2 (2–10) | 6·0 (3–10) | 4·1 (0–7) | 5·0 (2–8) | 5·2 (0–10) | 5·6 (0–10) | ||
| Communication | ||||||||||
| Non-verbal | 10·9 (4–14) | 11·5 (3–14) | 10·7 (3–14) | 10·6 (4–10) | 10·6 (6–14) | 10·8 (7–14) | 10·7 (3–14) | 11·0 (3–14) | ||
| Verbal | n=7 15·7 (9–20) |
n=4 15·2 (10–23) |
n=5 16·6 (10–21) |
n=9 15·6 (10–21) |
n=10 15·3 (12–19) |
n=11 16·0 (12–20) |
n=22 15·7 (9–21) |
n=25 15·7 (10–23) |
||
| ADOS-G† | ||||||||||
| Module 1 (at most single words) | n=21 | n=20 | n=22 | n=20 | n=17 | n=17 | n=60 | n=57 | ||
| Communication | 6·6 (4–8) | 6·7 (5–8) | 6·1 (4–8) | 5·8 (4–8) | 6·2 (4–8) | 5·8 (4–8) | 6·3 (4–8) | 6·1 (4–8) | ||
| Reciprocal social interaction | 11·2 (7–14) | 11·1 (7–14) | 10·8 (7–14) | 10·4 (7–14) | 10·5 (8–14) | 11·0 (8–14) | 10·9 (7–14) | 10·8 (7–14) | ||
| Module 2 (phrase speech) | n=5 | n=6 | n=4 | n=6 | n=8 | n=6 | n=17 | n=18 | ||
| Communication | 7·2 (6–8) | 7·2 (5–9) | 6·0 (5–7) | 6·0 (5–8) | 6·6 (5–9) | 7·0 (6–9) | 6·6 (5–9) | 6·7 (5–9) | ||
| Reciprocal social interaction | 9·2 (7–11) | 10·3 (9–13) | 9·5 (9–10) | 9·8 (7–13) | 8·9 (6–12) | 8·8 (6–14) | 9·1 (6–12) | 9·7 (6–14) | ||
| Module 1 and 2 RRB | 4·3 (1–6) | 4·1 (2–6) | 3·8 (0–6) | 3·7 (1–6) | 2·9 (1–5) | 3·2 (1–6) | 3·7 (0–6) | 3·7 (1–6) | ||
| Mullen non-verbal IQ age equivalent‡ | 25·0 (8·3) | 22·2 (7·6) | 24·8 (9·0) | 25·3 (8·0) | 31·3 (11·7) | 28·8 (11·9) | 27·0 (10·0) | 25·3 (9·5) | ||
Data are mean scores (range) or mean scores (SD). RRB=restricted and repetitive behaviour. IQ=intelligence quotient. PACT=Preschool Autism Communication Trial. TAU=treatment as usual.
Threshold scores are 8 for verbal communication and 7 for non-verbal communication; 10 for social; and 3 for RRBs.
Threshold scores for module 1 are: 4 for communication, 7 for social interaction, and 12 for communication-social total; and for module 2: 5 for communication, 6 for social interaction, and 12 for social-communication total.
Age-equivalents in months; for typically developing children, chronological age and IQ age-equivalents would be similar.