Table 2.
Allelic and genotypic frequencies of the VDR FokI C>T (F/f), BsmI A>G (B/b), ApaI T>G (A/a) and TaqI T>C (T/t) polymorphisms in controls and liver cirrhosis patients n (%)
| VDR | Control subjects (n = 236) | Liver cirrhosis (n = 240) | OR | 95% CI | P1 |
| F = 0.646 | F = 0.665 | 1 | Ref. | ||
| FokI | f = 0.354 | f = 0.335 | 1.085 | 0.831-1.417 | NS |
| B = 0.392 | B = 0.421 | 1 | Ref. | ||
| BsmI | b = 0.608 | b = 0.579 | 1.127 | 0.870-1.460 | NS |
| A = 0.570 | A = 0.590 | 1 | Ref. | ||
| ApaI | a = 0.430 | a = 0.410 | 1.084 | 0.838-1.402 | NS |
| T = 0.608 | T = 0.579 | 1 | Ref. | ||
| TaqI | t = 0.392 | t = 0.421 | 0.887 | 0.685-1.149 | NS |
| F/F = 104 (44.1) | F/F = 105 (43.8) | 1 | Ref. | ||
| FokI | F/f = 97 (41.1) | F/f = 109 (45.4) | 1.113 | 0.758-1.635 | NS |
| f/f = 35 (14.8) | f/f = 26 (10.8) | 0.736 | 0.416-1.303 | NS | |
| B/B = 41 (17.4) | B/B = 40 (16.7) | 1 | Ref. | ||
| BsmI | B/b = 103 (43.6) | B/b = 122 (50.8) | 1.214 | 0.732-2.014 | NS |
| b/b = 92 (39.0) | b/b = 78 (32.5) | 0.869 | 0.513-1.473 | NS | |
| A/A = 76 (32.2) | A/A = 80 (33.3) | 1 | Ref. | ||
| ApaI | A/a = 117 (49.6) | A/a = 123 (51.3) | 0.999 | 0.668-1.494 | NS |
| a/a = 43 (18.2) | a/a = 37 (15.4) | 0.817 | 0.477-1.400 | NS | |
| T/T = 89 (37.7) | T/T = 76 (31.7) | 1 | Ref. | ||
| TaqI | T/t = 109 (46.2) | T/t = 126 (52.5) | 1.354 | 0.909-2.017 | NS |
| t/t = 38 (16.1) | t/t = 38 (15.8) | 1.171 | 0.681-2.013 | NS |
The odds ratios were constructed with the wild type for each polymorphism as the reference. The statistical analysis was carried out using the Pearson χ2 test.
1
Pearson χ2 test; OR: Odds ratio; CI: Confidence interval; VDR: Vitamin D receptor.