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. 2010 Jun 22;119(Pt 7):273–282. doi: 10.1042/CS20100084

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© 2010 The Author(s) The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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(A) Increased binding between myocardin and SRF under 2.5% O₂ as determined using an EMSA. The binding between myocardin and SRF was suppressed by PD98059 and losartan. (B) Wild-type and myocardin mutant used for the luciferase assay. (C) Hypoxia (2.5% O₂) increased the transcriptional activity of myocardin when compared with the myocardin mutant (Mut) as determined using a luciferase reporter assay. The transcriptional activity was suppressed by PD98059 and losartan. Addition of exogenous AngII (10 nmol/l) increased the transcriptional activity in neonatal cardiomyocyte similar to that of 2.5% O₂. *P<0.01 compared with normoxia control; ^#P<0.01 compared with 6 h (n=3).