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. Author manuscript; available in PMC: 2010 Jun 24.
Published in final edited form as: Blood. 2009 Feb 9;113(15):3593–3599. doi: 10.1182/blood-2008-08-173641

Figure 7. Relationship between erythropoiesis rate and hepatic hepcidin expression.

Figure 7

(A) Spleen weight–body weight ratio in control, hypoxic, and EPO-treated mice (50 U for 4 days). (B) Spleen weight–body weight ratio and (C) hepatic hepcidin expression in mice treated with increasing amounts of EPO (total dosage over 4 days is shown) alone (CTL) and in combination with LPS or CI-supplemented diet (CI). (A–C) Data are presented as means plus or minus SD with n = 5 to 6 mice per group. Statistical analysis was performed by 1-way ANOVA; *P < .01 and **P < .001 for comparison with control mice. (D–F) Negative correlation between spleen weight–body weight ratio and hepatic hepcidin expression in mice treated with increasing amounts of EPO: (D) alone (EPO); (E) in combination with LPS (EPO + LPS); and (F) in combination with CI-supplemented diet (EPO + CI). Hepatic hepcidin expression was quantified by real-time RT-PCR and normalized to β-actin. The hepcidin/β-actin ratios are shown.