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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Biopolymers. 2010 Apr;93(4):370–382. doi: 10.1002/bip.21355

Figure 3. Impact of an Acrolein Adduct on Thermodynamic Stability of the DNA Host Duplex.

Figure 3

Comparison of excess heat capacity profiles determined for the α-OH-PdG·C (red) and α-OH-PdG·A (magenta) duplexes relative to the corresponding G·C parent (blue) and G·A mismatch (navy) 11-mers. The inset furnishes van’t Hoff analyses of the optically-derived concentration-dependent dissociation profiles for these four duplexes. The “undamaged” G·A mismatch and adduct-containing 11-mers paired with dA or dC significantly disrupt cooperative duplex dissociation with differential destabilization ranked as follows: G·A < α-OH-PdG·A < α-OH-PdG·C.