Skip to main content
. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Biopolymers. 2010 Apr;93(4):370–382. doi: 10.1002/bip.21355

Figure 4. Impact of α-OH-PdG and Opposite Base on non-ΔCp-corrected (light blue) and ΔCp-corrected (dark blue) Thermodynamic Parameters.

Figure 4

Differential thermodynamic destabilization of the G·C Parent sorted by decreasing order of energetic impact via replacement of dG by α-OH-PdG and/or dC by dA as specifically noted. The adduct-induced impacts on dissociation free energies are expressed as - ΔΔG to improve clarity and sorted on the basis of decreasing ΔCp-corrected ΔΔG. Replacement of dC with dA alleviates the overall energetic impact of α-OH-PdG irrespective of ΔCp-corrections, as noted by the observation that - ΔΔG < 0 for α-OH-PdG·C → α-OH-PdG·A.