Table 5.

Multivariate ORs^* for adenoma risk associated with intake of nitrite from meat (mg/day).

Characteristic	Quartile 1	Quartile 2	Quartile 3	Quartile 4	P Trenda	Continuous (per mg)
Nitrite
Median (Cut-points)	0.02 (≤ 0.03)	0.04 (>0.03–0.06)	0.08 (>0.06–0.12)	0.22 (>0.12)
Cases/Controls	40/161	43/161	34/158	38/156
OR (95% CI)	1.00	1.14 (0.67–1.93)	0.91 (0.52–1.59)	1.05 (0.59–1.86)	0.99	0.73 (0.15–3.58)

^*OR adjusted for age (continuous), education (high school or less, vocational/technical/business, 1–3 years or college/junior college, college graduate, graduate/professional degree), race (White, African-American, other), smoking status (never, former, current), physical activity (no moderate or vigorous activity, moderate, vigorous), BMI (continuous, kg/m²), study center (Bethesda, Portsmouth, San Diego, Washington D.C.), current HRT use (yes, no), family history of colorectal polyps or cancer (yes, no), regular NSAID use (defined as once a week for at least one month at any time prior to three months before colonoscopy; yes, no, don’t know/missing), alcohol intake (<5 g/day, 5–14.9 g/day, ≥15 g/day), fiber (continuous, g/1,000 kcal), dietary calcium (continuous, g/1,000 kcal), calcium from supplements (continuous, g/day), and total caloric intake (continuous, kcal/day).

^aP trend calculated using the median of each quartile.