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. Author manuscript; available in PMC: 2011 May 21.
Published in final edited form as: J Org Chem. 2010 May 21;75(10):3332–3338. doi: 10.1021/jo100361d

Table 1.

NCA Radiofluorination of (2-Methylphenyl)(phenyl)iodonium Salts in Different Solvents

Entry Anion Solvent Temp
(°C)		 Time
(s)		 RCY of [18F]fluoroarenes*
(%)		 Selectivity
for main
product
Total [18F]2-F-toluene [18F]F-benzene
1 Cl− MeCN-1.5% H2O 150 417 46 32 14 2.29
2 DMF ” 490 77 53 24 2.21
3 Br− MeCN-1.5% H2O ” 262 26 18 8 2.25
4 DMF 130 ” 99 67 32 2.09
5 I− MeCN-1.5% H2O 160 ” 12 8 4 2.00
6 DMF 130 354 48 33 15 2.54
7 OTs− MeCN 140 536 12 9 3 3.00
8 MeCN-1.5% H2O 150 322 50 34 16 2.13
9 DMF 130 474 98 66 32 2.06
*

Highest observed RCYs (the temperature and times are the conditions giving these yields).