Table 3.
Summary of effects of chronic metabotropic glutamate receptor 2/3 antagonist on performance in the 5-choice serial reaction time task.
Task measure | Pump Implantation main effect |
LY341495 main effect |
Implantation × LY341495 interaction |
Difference between LY341495 and vehicle groups during pump exposure in absence of phencyclidine (post-hoc) |
---|---|---|---|---|
accuracy | ↔ | ↔ | yes | not significant |
% correct responses | ⬇ | ↔ | yes | P < 0.01 |
% incorrect responses | ↔ | ↔ | no | not significant |
% omissions | ⬆ | ↔ | yes | not significant |
premature responses | ⬆ | ↔ | no | not significant |
timeout responses | ↔ | ↔ | no | not significant |
latency to correct response | ↔ | ↔ | no | not significant |
latency to reward retrieval | ↔ | ↔ | no | not significant |
total trials | ↔ | ↔ | yes | not significant |
The experimental groups did not differ significantly on any measure before minipump implantation.
⬇: significant decrease; ⬆: significant increase; ↔: no change.