Fig. 5.

Ranolazine affects SR Ca²⁺ content or NCX function insignificantly in ventricular myocytes from failing dog hearts. a Original traces of Ca²⁺ transients during the exposure to caffeine (10 mM) in control (left panel) and in the presence of ranolazine (RAN, 10 μM, right panel). b Average data for SR Ca²⁺ load, c average data for Ca²⁺ decay as a measure of NCX function (single exponential fit). Statistical analysis does not reveal a statistical difference between control and RAN for these parameters (ANOVA). Data bars in b and c represent mean ± SEM pooled from 8 to 15 cells