Table 1.
The demographic, clinical and pathological characteristics of 1989 men undergoing RP, within the DPC database, stratified by disease aggressiveness
| Mean (sd), median (IQR) or n (%) variable | Aggressive | Non-aggressive | P* |
|---|---|---|---|
| No. of patients | 100 | 1889 | |
| Age at surgery, years | 66.0 (7.1) | 63.6 (7.3) | 0.003† |
| Median year of surgery | 1993 | 1997 | < 0.001† |
| Race | 0.006 | ||
| Caucasian | 74 (74) | 1617 (86) | |
| African American | 24 (24) | 249 (13) | |
| Other | 2 (2) | 22 (1) | |
| BMI, kg/m2 | |||
| < 25 | 9 (19) | 292 (24) | 0.6 |
| 25–29.9 | 23 (49) | 583 (49) | |
| 30–34.9 | 10 (21) | 249 (21) | |
| ≥ 35 | 5 (11) | 75 (6) | |
| PSA, ng/mL | 21.5 (22.4) | 10.8 (29.8) | < 0.001† |
| 13.7 (8.4–25.0) | 6.8 (4.7–10.7) | ||
| Pathological Gleason sum | < 0.001 | ||
| 2–6 | 13 (13) | 988 (52) | |
| 7 | 45 (45) | 736 (39) | |
| 8–10 | 42 (42) | 165 (9) | |
| Prostate weight, g | 36.4 (15.0) | 41.6 (18.9) | 0.05† |
| 35.0 (26.5–44.0) | 37.0 (29.0–49.0) | ||
| % of prostate involved with cancer | 31.6 (19.2) | 17.0 (15.0) | < 0.001 |
| 25.0 (15.0–43.0) | 10.0 (5.0–22.0) | < 0.001 | |
| EPE | 68 (68) | 683 (36) | < 0.001 |
| Positive surgical margins | 59 (59) | 627 (33) | < 0.001 |
| SVI | 42 (42) | 180 (10) | < 0.001 |
| Pathological stage group | < 0.001 | ||
| Organ-confined, margin negative | 10 (10) | 926 (49) | |
| EPE and/or positive margins | 48 (48) | 783 (41) |
*
Chi-square test unless otherwise specified
†
Mann-Whitney test
IQR, interquartile range.