Table 3.
Stratification analysis of associations of the genotypes of the ADH1B and ADH7 with risk of SCCHN
| Stratified variables | No. (case/control) | ADH1B R48H rs1229984: G>A | P* | ADH7A92G rs1573496: C>G | P* | ||
|---|---|---|---|---|---|---|---|
| Percentage (case/control) | Adjusted OR (95% CI) † | Percentage (case/control) | Adjusted OR (95% CI) † | ||||
| GG | GG vs. AG + AA | CC | CC vs. CG + GG | ||||
| Age | |||||||
| ≤ 50 | 302/317 | 93.4/96.2 | 2.39 (1.12-5.10) | .025 | 85.5/80.4 | 0.74 (0.48-1.14) | .171 |
| 51 to 57 | 290/270 | 94.8/93.0 | 1.00 (0.47-2.10) | .996 | 84.5/80.7 | 0.90 (0.57-1.44) | .664 |
| ≥ 57 | 518/542 | 96.9/95.8 | 0.90 (0.45-1.79) | .757 | 85.7/79.2 | 0.67 (0.48-0.94) | .022 |
| Gender | |||||||
| Male | 837/859 | 95.3/95.2 | 1.26 (0.79-2.02) | .333 | 85.9/79.9 | 0.70 (0.54-0.91) | .008 |
| Female | 273/270 | 95.6/95.2 | 1.34 (0.57-3.14) | .501 | 83.9/80.0 | 0.90 (0.56-1.44) | .654 |
| Smoking status | |||||||
| Never | 308/552 | 91.6/94.4 | 1.59 (0.90-2.67) | .118 | 81.2/79.4 | 0.90 (0.63-1.28) | .547 |
| Former | 380/412 | 96.3/94.9 | 0.77 (0.38-1.54) | .453 | 85.8/79.9 | 0.68 (0.46-0.99) | .043 |
| Current | 422/165 | 97.4/98.8 | 2.14 (0.46-10.00) | .334 | 88.2/81.8 | 0.61 (0.36-1.01) | .055 |
| Alcohol use | |||||||
| Never | 304/494 | 91.8/93.3 | 1.39 (0.80-2.40) | .240 | 83.6/78.7 | 0.74 (0.51-1.07) | .110 |
| Former | 242/182 | 97.9/96.7 | 0.77 (0.22-2.68) | .682 | 85.1/76.9 | 0.67 (0.40-1.13) | .134 |
| Current | 564/453 | 96.3/96.7 | 1.35 (0.66-2.76) | .408 | 86.5/82.3 | 0.80 (0.56-1.14) | .219 |
| Primary tumor | |||||||
| T1 | 282/1129 | 95.0/95.2 | 1.24 (0.67-2.30) | .500 | 85.8/79.9 | 0.69 (0.48-1.01) | .055 |
| T2 | 401/1129 | 94.5/95.2 | 1.53 (0.90-2.61) | .113 | 85.8/79.9 | 0.72 (0.52-1.00) | .047 |
| T3 | 222/1129 | 96.4/95.2 | 1.05 (0.48-2.31) | .895 | 84.2/79.9 | 0.78 (0.52-1.17) | .226 |
| T4 | 204/1129 | 96.6/95.2 | 1.09 (0.47-2.55) | .828 | 85.3/79.9 | 0.76 (0.49-1.18) | .222 |
| Lymph node metastasis | |||||||
| N0 | 404/1129 | 96.5/95.2 | 0.93 (0.50-1.75) | .826 | 87.6/79.9 | 0.64 (0.45-0.90) | .010 |
| N1 | 160/1129 | 95.6/95.2 | 1.24 (0.54-2.86) | .611 | 86.9/79.9 | 0.63 (0.39-1.04) | .069 |
| N2 | 502/1129 | 94.0/95.2 | 1.62 (1.00-2.63) | .048 | 83.7/79.9 | 0.81 (0.60-1.07) | .140 |
| N3 | 43/1129 | 100.0/95.2 | -- | -- | 79.1/79.9 | 1.15 (0.54-2.47) | .720 |
| Tumor site | |||||||
| Oral cavity | 327/1129 | 94.5/95.2 | 1.48 (0.82-2.66) | .189 | 87.5/79.9 | 0.63 (0.43-0.91) | .014 |
| Pharynx ‡ | 609/1129 | 95.2/95.2 | 1.20 (0.74-1.94) | .466 | 83.9/79.9 | 0.80 (0.61-1.04) | .093 |
| Larynx | 174/1129 | 97.7/95.2 | 0.92 (0.31-2.73) | .877 | 86.8/79.9 | 0.68 (0.41-1.13) | .141 |
*
Two-side χ2 test obtained from multivariate logistic regression models with adjustment for age, sex, smoking and drinking status. The sum of subjects in some strata was less than the total number of subjects due to missing information.
†
Adjusted by age, sex, smoking and drinking status.
‡
Included 565 oropharynx cases and 44 hypopharynx cases.