Table 5.
FPRP Values for Associations Between risk of SCCHN and Frequencies of Genotypes and Haplotypes of ADH1B and ADH7
| Genotype / Haplotype | Positive OR (95% CI*) |
Statistical power‡ | Prior probability | |||||
|---|---|---|---|---|---|---|---|---|
| P† | .25 | .1 | .01 | .001 | .0001 | |||
| ADH7 A92G rs1573496: C>G | ||||||||
| GG vs. CC | ||||||||
| All subjects | 0.27 (0.11-0.68) | .000 | .007 | .115 | .281 | .812 | .978 | .998 |
| GG+CG vs. CC | ||||||||
| All subjects | 0.68 (0.54-0.85) | .001 | .548 | .003 | .010 | .098 | .522 | .916 |
| AGE ≥ 57 | 0.63 (0.46-0.87) | .005 | .373 | .039 | .110 | .575 | .932 | .993 |
| Male | 0.65 (0.50-0.84) | .001 | .421 | .007 | .021 | .190 | .703 | .960 |
| Former smoking | 0.66 (0.45-0.96) | .027 | .461 | .151 | .349 | .855 | .983 | .998 |
| N0 | 0.56 (0.40-0.78) | .001 | .152 | .010 | .029 | .246 | .767 | .971 |
| Oral cavity | 0.57 (0.40-0.82) | .002 | .197 | .028 | .080 | .489 | .906 | .990 |
| Haplotype§ | ||||||||
| A-C vs. G-C | 0.53 (0.28-0.99) | .001 | .020 | .095 | .240 | .776 | .972 | .997 |
| G-G vs. G-C | 0.68 (0.55-0.85) | .001 | .601 | .003 | .010 | .103 | .538 | .921 |
*
The crude OR.
†
The omnibus chi-square test of the genotype and haplotype frequency distributions.
‡
Statistical power was calculated using the number of observations in the subgroup and the OR and P values in this table.
§
Haplotypes constructed as the order of ADH1B R48H and ADH7 A92G