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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Trends Immunol. 2010 Jun 1;31(6):220–227. doi: 10.1016/j.it.2010.04.002

Figure 3.

Figure 3

TGF-β affects multiple components of the immune system. TGF-β inhibits the function of natural killer (NK) and CD8+ CTL (cytotoxic T lymphocytes), blocking the ‘cytotoxic program’ key proteins such as perforin, granzymes and cytotoxins. TGF-β induces Treg and Th17 cell differentiation and inhibits B-cell proliferation and IgA secretion. In addition, TGF-β inhibits dendritic function, block type I macrophage and neutrophil development but promotes type II macrophages and neutrophils, and mediates the immune suppression function of MISCs.