Table 3.
GWAS results with q-values smaller than 0.25
| Outcome | SNP | Gene symbol | Cytogenetic location | MAF | N | Eff | p-value | q-value | lFDR |
|---|---|---|---|---|---|---|---|---|---|
| Perphenazine - HDL | rs11163585 | no | 1p31.1 | 0.241 | 139 | + | 9.32E-07 | 0.249 | 0.614 |
| Perphenazine - Triglycerides | rs17410015 | no | 1p21.2 | 0.063 | 138 | + | 1.52E-06 | 0.117 | 0.429 |
| Perphenazine - Triglycerides | rs6735179 | no | 2p25.3 | 0.346 | 138 | + | 1.34E-07 | 0.018 | 0.08 |
| Perphenazine - Triglycerides | rs6741819 | RNF144A | 2p25.1 | 0.305 | 138 | + | 2.43E-07 | 0.029 | 0.127 |
| Risperidone - Hip Circumference | rs1991126 | no | 2p24.1 | 0.15 | 265 | + | 8.98E-07 | 0.112 | 0.437 |
| Risperidone - Hip Circumference | rs1117324 | no | 2p24.1 | 0.156 | 265 | + | 3.47E-07 | 0.054 | 0.245 |
| Perphenazine - Triglycerides | rs10202231 | no | 2p16.1 | 0.457 | 138 | - | 7.31E-07 | 0.068 | 0.279 |
| Clozapine - Heart Rate | rs399885 | no | 2p12 | 0.327 | 52 | + | 5.11E-07 | 0.135 | 0.356 |
| Clozapine - Heart Rate | rs7570469 | no | 2p12 | 0.418 | 52 | + | 5.50E-07 | 0.141 | 0.369 |
| Clozapine - Triglycerides | rs1534238 | no | 2p11.2 | 0.381 | 52 | - | 2.82E-06 | 0.218 | 0.583 |
| Clozapine - Triglycerides | rs17385675 | no | 2q33.1 | 0.069 | 53 | + | 3.44E-06 | 0.247 | 0.626 |
| Perphenazine - Triglycerides | rs13134954 | no | 4q23 | 0.337 | 135 | + | 2.19E-06 | 0.152 | 0.513 |
| Perphenazine - Triglycerides | rs11735070 | no | 4q23 | 0.338 | 137 | + | 1.30E-06 | 0.105 | 0.395 |
| Ziprasidone - Hip Circumference | rs1405687 | no | 4q23 | 0.088 | 183 | - | 4.72E-08 | 0.038 | 0.181 |
| Olanzapine - Hemoglobin A1c | rs1967256 | GPR98 | 5q14.3 | 0.148 | 207 | + | 2.80E-08 | 0.012 | 0.068 |
| Olanzapine - Hemoglobin A1c | rs11954387 | GPR98 | 5q14.3 | 0.148 | 207 | + | 2.80E-08 | 0.012 | 0.068 |
| Risperidone - Hemoglobin A1c | rs17100498 | no | 5q31.3 | 0.126 | 186 | + | 4.90E-07 | 0.078 | 0.236 |
| Risperidone - Hemoglobin A1c | rs17100506 | no | 5q31.3 | 0.126 | 184 | + | 7.45E-07 | 0.103 | 0.301 |
| Clozapine - Glucose | rs9658108 | PPARD | 6p21.31 | 0.052 | 53 | + | 4.58E-07 | 0.191 | 0.478 |
| Clozapine - Triglycerides | rs1577917 | no | 6q14.3 | 0.21 | 53 | + | 3.48E-06 | 0.248 | 0.628 |
| Clozapine - Total Cholesterol | rs1979096 | no | 7p21.1 | 0.115 | 53 | - | 6.02E-07 | 0.157 | 0.392 |
| Clozapine - Total Cholesterol | rs10499504 | no | 7p21.1 | 0.11 | 52 | - | 4.34E-07 | 0.129 | 0.334 |
| Clozapine - Triglycerides | rs13224682 | PRKAR2B | 7p22.3 | 0.072 | 53 | + | 6.30E-08 | 0.015 | 0.055 |
| Olanzapine - Total Cholesterol | rs977396 | no | 8q22.3 | 0.089 | 261 | + | 3.27E-07 | 0.173 | 0.463 |
| Clozapine - Glucose | rs320209 | no | 9q31.1 | 0.068 | 53 | + | 3.94E-07 | 0.174 | 0.448 |
| Perphenazine - Triglycerides | rs4838255 | ASTN2 | 9q33.1 | 0.139 | 135 | + | 2.62E-07 | 0.031 | 0.135 |
| Clozapine - Triglycerides | rs17661538 | no | 10p12.33 | 0.138 | 51 | + | 1.30E-06 | 0.131 | 0.415 |
| Clozapine - Triglycerides | rs2994684 | no | 10p11.22 | 0.155 | 53 | + | 2.58E-07 | 0.041 | 0.153 |
| Clozapine - Triglycerides | rs1771628 | no | 10p11.22 | 0.191 | 53 | + | 6.66E-07 | 0.082 | 0.286 |
| Risperidone - Hip Circumference | rs7119817 | no | 11q23.1 | 0.371 | 264 | + | 4.51E-07 | 0.067 | 0.292 |
| Risperidone - Hip Circumference | rs7105881 | no | 11q23.1 | 0.367 | 265 | + | 3.27E-07 | 0.052 | 0.235 |
| Risperidone - Hip Circumference | rs7108821 | no | 11q23.1 | 0.367 | 263 | + | 4.21E-07 | 0.063 | 0.279 |
| Clozapine - Triglycerides | rs620875 | KIRREL3 | 11q24.2 | 0.101 | 53 | + | 3.20E-06 | 0.236 | 0.61 |
| Perphenazine - HDL | rs1464500 | SOX5 | 12p12.1 | 0.232 | 138 | + | 1.07E-07 | 0.058 | 0.204 |
| Quetiapine - HDL | rs518590 | no | 13q12.11 | 0.21 | 253 | + | 1.60E-07 | 0.14 | 0.416 |
| Perphenazine - Total Cholesterol | rs1187614 | CLMN | 14q32.13 | 0.313 | 138 | - | 2.37E-07 | 0.23 | 0.541 |
| Risperidone - Hip Circumference | rs1568679 | MEIS2 | 15q14 | 0.103 | 265 | + | 1.28E-08 | 0.004 | 0.018 |
| Risperidone - Waist Circumference | rs1568679 | MEIS2 | 15q14 | 0.103 | 266 | + | 6.82E-08 | 0.055 | 0.244 |
| Risperidone - Hemoglobin A1c | rs13335336 | ATF7IP2 | 16p13.13 | 0.078 | 187 | + | 7.09E-07 | 0.1 | 0.293 |
| Perphenazine - Triglycerides | rs153091 | LOC729993 | 16p13.12 | 0.227 | 138 | + | 1.85E-06 | 0.135 | 0.474 |
| Olanzapine - Total Cholesterol | rs4783227 | no | 16q23.3 | 0.424 | 269 | - | 3.95E-07 | 0.194 | 0.502 |
| Clozapine - Triglycerides | rs17216786 | CDH13 | 16q23.3 | 0.054 | 53 | + | 1.33E-06 | 0.133 | 0.42 |
| Perphenazine - Triglycerides | rs17651157 | FHOD3 | 18q12.2 | 0.068 | 138 | + | 1.07E-07 | 0.016 | 0.067 |
| Perphenazine - Triglycerides | rs10502661 | FHOD3 | 18q12.2 | 0.063 | 138 | + | 1.61E-07 | 0.021 | 0.093 |
| Risperidone - Hemoglobin A1c | rs8092443 | no | 18q22.2 | 0.225 | 186 | - | 9.72E-07 | 0.123 | 0.348 |
| Risperidone - Hemoglobin A1c | rs11663206 | no | 18q22.2 | 0.289 | 187 | - | 2.07E-06 | 0.197 | 0.498 |
| Risperidone - Hip Circumference | rs6092078 | no | 20q13.2 | 0.115 | 264 | - | 2.61E-06 | 0.238 | 0.681 |
Locus information includes gene in region, cytogenetic location, location of SNP, and the minor allele frequency (MAF) calculated in the complete CATIE sample. For each test we report the sample size (N), direction of effect of minor allele frequency (Eff) where a “+” indicates positive association, q values and local FDRs as estimated using the method developed by Bukszar et al.44, and the number of other analyzed outcomes showing significant association to the SNP at p<.05 (#m). Genomewide significant results are indicated in bold. Consecutive shaded rows indicate SNPs in high LD (r2 > 0.8).